Fem Dophilus Brochure- The Superior Vaginal Probiotic Formula Because Not All Probiotics Are the Same….

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• Specifically Promotes Vaginal and Urinary- Genital Health Naturally

• Supplies Patented Lactobacillus GR-1™* and Lactobacillus RC-14™*

• Clinically Proven and Backed by Over Twenty Years of Research

• Colonizes and Protects the Vaginal Tract

What Is Fem-Dophilus?

Fem-Dophilus™ contains two patented and clinically tested strains of probiotic bacteria, Lactobacillus rhamnosus GR-1™ and Lactobacillus reuteri RC- 14™, discovered and developed by Drs. Gregor Reid and Andrew Bruce of Urex Biotech. Research has confirmed that GR-1 and RC-14 taken as an oral supplement colonize and protect the vaginal tract. Over twenty years of clinical trials has shown that GR-1 and RC-14 help to restore and maintain the balance of flora important to vaginal health and the health of the urinary tract overall.

This patented product is manufactured at a Good Manufacturing Practices (GMP) pharmaceutical facility under strict quality control to ensure potency and consistency. The probiotic strains in Fem-Dophilus™ are delivered in a proprietary polysaccharide matrix that protects the bacteria from stomach acid and enhances the survival of these species as they reach the intestinal tract.

How Probiotics Support Vaginal Health

Daily support for the gastrointestinal tract by orally taking friendly microflora is important for many health reasons. Purchasers of other Jarrow FORMULAS® probiotics products are already aware of the many health benefits that can be experienced from supplementing with beneficial bacteria, i.e. probiotics. For instance, Jarro-Dophilus EPS™ is designed to boost the natural “friendly” bacteria of the gut by supplying useful amounts of the most beneficial strains that are needed to maintain a healthy intestinal environment. Jarro-Dophilus EPS™ is a compatible blend of friendly bacteria designed to restore the proper intestinal balance. Restoring the balance of microorganisms to the gut both helps to crowd out unwanted organisms and promote proper immune response, as well. Less well known is the fact that special strains of probiotic bacteria active in the digestive tract also contribute to vaginal health.

It has been established that women with an unhealthy intestinal microflora profile are at a higher risk of developing urogenitial infections. Fortunately, scientific findings indicate that supportive microflora capable of colonizing the vagina can play an important role in maintaining health. This suggests that the daily ingestion of certain probiotics might provide a natural, safe and effective means of contributing to a healthful balance of microorganisms in both the intestinal and vaginal tracts.

Clinical research supports the proposition that proper use of oral probiotics can do just this. For instance, researchers have shown this in the article, “Oral use of Lactobacillus rhamnosus GR-1 and L. fermentum RC-14 significantly alters vaginal flora: randomized, placebo-controlled trial in 64 healthy women.” (FEMS Immunol Med Microbiol 2003;35:131-134.)

Oral Intake of Probiotics Influences Vaginal Floral Balance

Clinical trials have examined whether probiotics taken orally can influence vaginal floral balance and, likewise, whether all probiotics have such benefits. The answer to the first issue is that, yes, an intake of probiotics as an oral supplement can significantly and beneficially affect the balance of vaginal flora. However, the answer to the second issue is that only certain probiotics can provide this benefit. Direct comparisons have demonstrated that the probiotic species and strains must be carefully selected in order to significantly and beneficially influence vaginal health.

The major criteria required in selecting beneficial probiotics are their ability to colonize the vagina and reduce undesirable vaginal microflora. In one trial, GR-1 and RC-14 administered in skim milk were given orally to 10 women twice daily for 14 days. GR-1 and RC-14 were recovered from the vagina and identified by morphology and molecular typing within 1 week of commencement of the trial. In another randomized, placebo-controlled trial, GR-1 and RC-14 were given to 64 women for 60 days. Microscopy analysis showed the restoration of healthy vaginal flora level in 37% of women taking GR-1 and RC-14 vs. 13% in subjects in placebo group. Other trials have also confirmed the benefits of GR-1 and RC-14 intake.

In order for a probiotic to be effective, of course, significant numbers of live bacteria (indicated as Colony Forming Units or CFU) must survive when the probiotic is taken by mouth. Tests for the gastrointestinal survivability of strains have shown good results. GR-1 and RC-14 are bile tolerant and survive passage through the gastrointestinal tract. This in vivo result confirms what might be expected from test tube research. For instance, an in vitro study has shown that RC-14 and GR-1 are tolerant to 0.3 and 0.5 percent (w/v) bile, respectively. According to the experts, both strains can therefore be considered both acid and bile tolerant given that a concentration of 0.3 percent is considered physiologically relevant.

Advanced Science and Technology

Several human and in vitro studies have documented the safety of GR-1 and RC-14. The Jarrow FORMULAS® Fem-Dophilus™ product is provided by a pharmaceutical GMP level manufacturer that uses advanced and accurate genetic analyses to ensure correct identity of the strains and that the strains remain constant over time. This is the ultimate in quality control.

Usage

For maintenance, take 1 capsule per day with water after a meal. Increase to 2 capsules per day for additional support as indicated in the discussion above, or use as directed by your qualified health consultant.

References

Bruce AW et al. Preliminary study on the prevention of recurrent
urinary tract infections in adult women using intravaginal
Lactobacilli. Int Urogynecol J 1992; 3: 22-25.
Cadieux P et al. Lactobacillus strains and vaginal ecology
JAMA 2002; 287: 1940-1941.
Gardiner GE et al. Oral administration of the probiotic combination
Lactobacillus rhamnosus GR-1 and L.fermentum RC-14
for human intestinal applications. Int Dairy J 2002; 12: 191-196.
Reid G et al. Oral use of Lactobacillus rhamnosus GR-1 and
L.fermentum RC-14 significantly alters vaginal flora: randomized,
placebo-controlled trial in 64 healthy women. FEMS
Immunol Med Microbiol 2003; 35: 131-134.
Reid G et al. Effect of Lactobacilli Oral supplement on the
vaginal microflora of antibiotic treated patients: Randomized,
placebo-controlled study. Nutr Food 2003; 8: 145-148.
Reid G et all. Probiotic Lactobacillus dose required to restore
and maintain a normal vaginal flora. FEMS Immunol Med
Microbiol 2001; 32: 37-41.
Reid G et al. Oral probiotics resolve urogenitial infection. FEMS
Immunol Med Microbiol 2001; 30: 49-52.
Reid G et al. Instillation of Lactobacillus and stimulation of
indigenous organisms to prevent recurrence of urinary tract
infections. Microecol Ther 1995; 23: 32-45.
Reid G et al. Influence of three-day antimicrobial therapy and
Lactobacillus vaginal suppositories on recurrence of urinary
tract infections. Clin Ther 1992; 14 (1): 11-16.

Source: Jarrow Formulas